Slay the Spire 2 Best Builds

Switch between Wrath and Calm stances for massive damage multipliers. Focus on stance-changing cards and high-damage finishers.

Build Divinity through stance changes, then unleash devastating combos with free energy.

Apply Doom quickly to summon minions instantly. Combine with minion buff cards for overwhelming board presence.

Focus on summoning multiple minions and buffing them with damage and health bonuses.

Maximize Focus stat to amplify Lightning orb damage. Scale exponentially in late game.

Use Dark orbs for energy generation and controlled burst damage when needed.

Apply multiple poison stacks and scale with Catalyst. Kills bosses in few turns.

Generate and play multiple Shivs per turn with Accuracy buffs for consistent damage.

Stack Strength buffs through combat for exponential damage scaling.

Focus on defense and outlast enemies with massive block generation.